Medically reviewed by Rosanna Sutherby, PharmD on January 10, 2020. Written by Kathryn Wall. To give you technically accurate, evidence-based information, content published on the Everlywell blog is reviewed by credentialed professionals with expertise in medical and bioscience fields.
Concerned because you've noticed yellow skin around the eyes—and the skin throughout the rest of your body has taken on an abnormal yellow tint, as well?
Yellowing of the skin and/or the whites of the eyes is a classic sign of jaundice—a condition that can occur when there's a buildup of a certain natural pigment (bilirubin) in the bloodstream. If you suspect jaundice may be affecting you, read on to discover more—including possible causes, related health conditions, prevention tips, and more. (And don't forget to discuss your symptoms with your healthcare provider as soon as possible.)
Jaundice is directly caused by high bilirubin levels in the body. Bilirubin, a yellow-orange pigment in the bloodstream, primarily forms when aged red blood cells are broken down. Normally, the liver filters bilirubin from the bloodstream and moves it into the digestive tract where it is then eliminated in stool and urine.
However, when the liver isn't functioning properly—or if bilirubin production significantly increases for some reason—this substance builds up in the bloodstream and can cause a yellow discoloration of the skin and whites of the eyes.
Other signs and symptoms of high bilirubin levels may include:
A number of factors can lead to higher-than-normal levels of bilirubin, resulting in jaundice—such as the following.
Vitamin B12 plays an important role in the development of red blood cells. This essential B vitamin can be obtained through meat, poultry, eggs, and nutritional supplements. A deficiency in vitamin B12 can lead to low levels of healthy red blood cells, leading to a type of anemia called pernicious anemia. Symptoms of pernicious anemia may include diarrhea, loss of appetite, and jaundice.
To conveniently check if you could be deficient in vitamin B12, take the Everlywell at-home B Vitamins Test—which measures not just your B12 level, but also your levels of two other important B vitamins: B6 and B9.
Hepatitis B occurs when someone is infected by the hepatitis B virus—which can damage the liver if it isn't treated promptly. The hepatitis B virus can be transmitted through body fluids such as semen and blood during activities like sexual intercourse and needle-sharing. Joint pain, dark urine, and jaundice are all symptoms of hepatitis B.
Hepatitis C occurs when someone is infected by the hepatitis C virus. Hepatitis C can cause serious harm to the liver over time and is characterized by many of the same symptoms of hepatitis B—including nausea, vomiting, and jaundice. Estimates suggest that about 1 in 5 cases of acute hepatitis C results in jaundice.
You can confidentially test for hepatitis C—without leaving your home—with our at-home Hepatitis C Test. Note that the Centers for Disease Control and Prevention (CDC) recommends that all adults age 18+ get tested for hepatitis C at least once.
Certain drugs and medications like painkillers, nonsteroidal anti-inflammatory drugs, anabolic steroids, birth control pills, and statins can hurt the liver and cause jaundice. Liver damage that occurs as a result of these medications is called drug-induced liver injury, which is characterized by symptoms including dark urine, fever, and jaundice.
Before bilirubin is eliminated from the body, it moves through the bile duct into the digestive tract. Blockage in the bile duct can cause bilirubin to build up in the bloodstream, which can result in yellow skin discoloration. In many cases, blockages in the bile duct are caused by a gallstone, but some may be caused by cancer tumors or rare liver disorders. Surgery is one of the most common treatments for bile duct obstruction.
The liver is responsible for breaking down alcohol in the body. However, drinking high amounts of alcohol on a regular basis can overload the liver, ultimately causing liver damage and liver disease. When the liver becomes damaged, it may have difficulty filtering bilirubin from the bloodstream—and jaundice may develop.
People who have been drinking heavily for many years are at higher risk of developing alcoholic liver disease. Over time, alcohol abuse can worsen liver function and contribute to high bilirubin levels, abdominal pain, and yellow skin on the hands and the rest of the body.
Gallbladder cancer is a possible complication of gallstones—hardened deposits of digestive fluid that can form in the gallbladder as a result of a high-cholesterol, high-fat diet, or high levels of bilirubin. Excess bilirubin contributes to the formation of gallstones, which can block the bile duct, preventing bilirubin from exiting the body.
Liver cancer is caused by long-term damage and scarring of the liver due to alcohol abuse, hepatitis B and C, autoimmune diseases of the liver, or other factors. Common symptoms of liver cancer include abdominal pain, an enlarged abdomen, unexplained weight loss, and jaundice. Treatment options for liver cancer can include surgery or liver transplantation.
If you notice that your skin is turning yellow or you develop a yellow tinge in the whites of the eyes, see your healthcare provider as soon as possible to receive a proper diagnosis. A healthcare professional may help identify the root cause of your jaundice and start a treatment regimen, if necessary. To determine the cause of jaundice, laboratory tests (such as liver function tests), imaging tests, and/or a liver biopsy may be recommended.
Seek medical attention right away if you're experiencing any of the following symptoms with jaundice:
The above symptoms may indicate a serious medical condition that requires immediate treatment.
Steps you can take that may help prevent jaundice include:
Yellowing of the skin—whether it's one spot or an all-over discoloration—may be an indication of jaundice. It could be due to something else, however. So the best course of action to take if you notice a yellow spot on your skin? See your healthcare provider as soon as possible, as they can help determine what the cause is.
Though jaundice may be one of the most common signs of liver disease, it's possible to have liver disease with delayed jaundice or without jaundice. Other symptoms of liver disease may include fatigue, weakness, fever, nausea, vomiting, dark urine, light-colored stool, and pain under the right side of the ribs.
1. Kalakonda A, Jenkins BA, John S. Physiology, Bilirubin. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020. Available from: URL. Accessed January 10, 2020.
2. Stillman AE. Jaundice. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Available from: URL. Accessed January 10, 2020.
3. Pernicious anemia. MedlinePlus. URL. Accessed January 10, 2020.
4. Hepatitis B. National Institute of Diabetes and Digestive and Kidney Diseases. URL. Accessed January 10, 2020.
5. Hepatitis C. National Institute of Diabetes and Digestive and Kidney Diseases. URL. Accessed January 10, 2020.
6. Lohia P, Jinjuvadia R, May E. Profound jaundice in a patient with acute hepatitis C. BMJ Case Rep. 2013;2013:bcr2013200233. Published 2013 Sep 12. doi:10.1136/bcr-2013-200233
7. Testing Recommendations for Hepatitis C Virus Infection. Centers for Disease Control and Prevention. URL. Accessed January 10, 2020.
8. Drug-induced liver injury. MedlinePlus. URL. Accessed January 10, 2020.
9. Maher JJ. Exploring alcohol's effects on liver function. Alcohol Health Res World. 1997;21(1):5-12.
10. Gallstones. Mayo Clinic. URL. Accessed January 10, 2020.
11. Liver cancer - hepatocellular carcinoma. MedlinePlus. URL. Accessed January 10, 2020.
12. 13 Ways to a Healthy Liver. American Liver Foundation. URL. Accessed January 10, 2020.
13. Symptoms of liver disease. U.S. Department of Veterans Affairs. URL. Accessed January 10, 2020.